Does Oral Acetaminophen Lower Intraocular Pressure?

Completed · Early Phase 1

Conditions studied: Glaucoma

In brief

\- Lowering intraocular pressure is the only proven treatment for glaucoma. Medications, almost always in the form of eye drops, are a mainstay for lowering intraocular pressure. Eye drops have the disadvantage of being difficult to administer and can have adverse effects on the surface of the eye and the surrounding tissues. Lowering intraocular pressure can be accomplished with oral carbonic anhydrase inhibitors, but the many systemic side effects of these agents relegates them to drugs of last resort. Therefore, an effective, well-tolerated, oral agent would be an important addition to the treatment of glaucoma. The hypothesis is that oral acetaminophen can lower intraocular pressure to a clinically significant degree in a dosing regimen that is both safe and convenient. The research is important because acetaminophen is inexpensive, available over-the-counter, and has a well known safety and side effect profile.

Key facts

Study ID

NCT02366065

Run by

Johns Hopkins University

People needed

11

Starts

2015-01-01

Expected to finish

2016-05-01

Last updated by the study team

2016-06-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• not on intraocular pressure lowering medications for at least 6 weeks in either eye.
• IOP above 22 mm Hg and below 35 mm Hg in at least one eye. The eye with the higher IOP will be the study eye

You may not qualify if…

• using acetaminophen
• history of hepatic disease either reported by the patient or documented in the patient's medical record

Where it is running

• Johns Hopkins - The Wilmer Eye Institute — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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