Transplant Optimization Using Functional Imaging

Completed · Not applicable

Conditions studied: Bronchiolitis Obliterans, Lung Transplant Rejection

In brief

The objective of this study is to detect Bronchiolitis Obliterans Syndrome (BOS) in an early stage using the outcome parameters generated by Functional Respiratory Imaging (FRI). Robust and automated segmentation algorithms will be developed for these parameters, focusing on quantitative computed tomography (CT) image analyses to provide the physician a more sensitive diagnostics tool. The evolution of BOS over time will be monitored using non-rigid image registration methods.

Key facts

Study ID

NCT02364674

Run by

FLUIDDA nv

People needed

8

Starts

2015-02-01

Expected to finish

2017-01-09

Last updated by the study team

2017-03-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patient ≥ 18 years old
• Written informed consent obtained
• Patient who had undergone a lung transplant a year ago or more.
• Female patient of childbearing potential who confirm that a contraception method was used at least 14 days before visit 1 and will continue to use a contraception method during the study
• The patient must be able to perform the lung monitoring at home.

You may not qualify if…

• Pregnant or lactating female
• Known history of or active airways or anastomotic complications requiring intervention such as stenting or dilation

Where it is running

• Columbia University Medical Center — New York, New York, United States
• Hospital of the University of Pennsylvania — Gibson, Pennsylvania, United States

Full record on ClinicalTrials.gov

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