Lidocaine for Diabetic Peripheral Neuropathy

Completed · Not applicable · Has a placebo group

Conditions studied: Diabetes, Peripheral Neuropathy, Pain

In brief

Diabetic nerve pain \[painful diabetic peripheral neuropathy\] is a common medical problem with few reliably effective treatments. There is some evidence that sensory testing may help determine how individuals will respond to analgesic therapy. In this study, the investigators are evaluating the relationship between sensory testing and subject response to lidocaine infusion therapy.

Key facts

Study ID

NCT02363803

Run by

Washington University School of Medicine

People needed

34

Starts

2015-02-01

Expected to finish

2018-10-17

Last updated by the study team

2019-11-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18;
• Diagnosis of Diabetes Mellitus (Fasting Plasma Glucose > 126 mg/dL and/or HbA1C >6.5%);
• Distal symmetric pain in lower extremities with duration of more than 3 months;
• Presence of either numbness or at least 1 sensory disturbance (increased or decreased sensitivity) in the feet.
• Spontaneous pain with intensity of ≥ 4 on 0-10 Numerical Rating Scale (NRS).

You may not qualify if…

• Not giving consent to participate in the study;
• Unable to complete self-report pain questionnaire;
• History of moderate to severe renal or liver failure;
• History of other central or peripheral neurologic disorders;
• History of cardiac arrhythmias;
• Contraindication to intravenous lidocaine;
• Pregnancy or lactation.

Where it is running

• Washington University School of Medicine/Barnes Jewish Hospital — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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