Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease

Completed · Not applicable

Conditions studied: Chronic Kidney Diseases, Deficiency, Vitamin D

In brief

This study investigates the effect of vitamin D deficiency on drug metabolism and transport in patients with chronic kidney disease (CKD) and in healthy controls. The central hypothesis is that vitamin D concentrations independently affect metabolism and transport function in CKD patients. An over-arching goal of this proposal is to make drug therapies safer and more effective to reduce the significant morbidity and mortality in patients with CKD.

Key facts

Study ID

NCT02360644

Run by

University of Colorado, Denver

People needed

23

Starts

2014-10-01

Expected to finish

2019-02-01

Last updated by the study team

2021-06-30

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

Where it is running

• University of Colorado — Aurora, Colorado, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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