Rasagiline Rescue in Alzheimer's Disease Clinical Trial

Completed · Phase 2 · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

This is a Phase II, randomized, double blind, placebo controlled, parallel group, proof of concept three-site study, to evaluate the effect of Rasagiline in the regional brain metabolism on 18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose (FDG-PET).

Key facts

Study ID

NCT02359552

Run by

The Cleveland Clinic

People needed

50

Starts

2015-05-01

Expected to finish

2019-01-04

Last updated by the study team

2020-11-10

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females 50 to 90 of age inclusive.
• Diagnosis of probable AD (NINCDS-ADRDA criteria)
• Positive fluoro-deoxyglucose PET ([18F]-FDG PET) scan compatible with AD as determined by the ADM Diagnostics LLC (ADMdx) Criteria at screening
• Mini Mental Status Exam = 12 - 22 (inclusive)
• Must have a study partner who is able and willing to comply with all required study procedures.
• Have at least eight years of education and should have previously (in pre-AD condition) been capable of reading, writing, and communicating effectively with others in English.
• If receiving therapy with a cholinesterase inhibitor and/or memantine, the dose of these agents has been stable for at least 3 months prior to screening

You may not qualify if…

• Any non-AD neurological disease
• MRI findings indication of a non-AD diagnosis
• Screening laboratory studies that are 1.5 times above or below the highest and lowest range of normal for each test respectively
• History of melanoma; history of malignancy within the past five years with the exception of basal cell or squamous cell cancer, in-situ cervical cancer, or localized prostate cancer

Where it is running

• Cleveland Clinic Lou Ruvo Center for Brain Health — Las Vegas, Nevada, United States
• Cleveland Clinic Main Campus — Cleveland, Ohio, United States
• Cleveland Clinic Lakewood Hospital — Lakewood, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.