Genetic Variation and Variability in Posaconazole Pharmacokinetics in Children

Completed · Phase 1

Conditions studied: Fungal Infections

In brief

The main goal of this study is to see how the body breaks down an antifungal drug named posaconazole in children with certain cancers, blood disorders, or transplantation of bone marrow or similar blood cells. This study will also help us learn whether a child's age, genetics, or disease affect how well the body breaks down posaconazole.

Key facts

Study ID

NCT02358499

Run by

Children's Mercy Hospital Kansas City

People needed

31

Starts

2015-01-01

Expected to finish

2018-12-31

Last updated by the study team

2020-12-22

Who can join

Age: 2 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 2 years to under 18 years
• Weight ≥10 kg
• Diagnosis of any of the following: any malignancy (e.g., acute myelogenous leukemia [AML], acute lymphoblastic leukemia [ALL], lymphoma, solid tumor malignancy), hemophagocytic syndrome, bone marrow failure syndrome (e.g., myelodysplastic syndrome and aplastic anemia), hematopoietic stem cell transplantation (HSCT) recipient, or primary immune deficiency with a neutrophil or T-cell defect (e.g., chronic granulomatous disease, hyper IgE syndrome, severe combined immune deficiency).

You may not qualify if…

• A female subject must not be pregnant, intend to become pregnant during the study, or breastfeed
• A subject must not be receiving any of the following medications within 24 hours before or after posaconazole infusion (or according to standard of care protocols): sirolimus, everolimus, pimozide, quinine, HMG-CoA reductase inhibitors primarily metabolized through CYP3A4 (e.g., atorvastatin, lovastatin, simvastatin), ergot alkaloids (ergotamine, dihydroergotamine), methadone, astemizole, cisapride, halofantrine, salmeterol, or vincristine. Potential enrollees will be screened for additional concomitant medications that pose serious safety concerns when given concomitantly to posaconazole. Any of these medications will be an exclusion criterion, unless the concomitant medications may be held for 24 hours before and after posaconazole infusion or according to standard of care protocols
• A subject must not be receiving any of the following medications concomitant (within 5 half-lives prior) to posaconazole infusion or PK sampling: rifampin, rifapentine, rifabutin, phenytoin, efavirenz, fosamprenavir, or cimetidine. Potential enrollees will be screened for additional concomitant medications that may affect posaconazole metabolism. Any of these medications will be an exclusion criterion, unless the concomitant medications may be held for 5 half-lives prior to posaconazole infusion and through PK sampling
• A subject must not have moderate or severe liver dysfunction (except in chronic cases as judged by the P.I.) at Baseline, defined as:
• A subject must not have moderate or severe liver dysfunction at Baseline, defined as: Aspartate aminotransferase (AST) > 5 times the upper limit of normal (ULN), OR
• Alanine aminotransferase (ALT) > 5 times the ULN, OR
• Serum total bilirubin >2.5 times the ULN, OR
• A subject must not have an electrocardiogram (ECG) with prolonged age, sex-adjusted QTc interval.
• A subject must not have a history of dysrhythmia.
• A subject must not have creatinine clearance levels (measured or calculated) below 50 mL/min/1.73 m2.
• A subject must not have a history of Type 1 hypersensitivity or idiosyncratic reactions to azole agents.

Where it is running

• Children's Mercy Hospital Kansas City — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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