GnRH for Luteal Support in IVF/ICSI/FET Cycles

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Infertility

In brief

During IVF cycles an embryo is generally placed into the uterine cavity between 3 and 5 days after fertilization. For a successful pregnancy to take place, that embryo must then implant in the properly primed and staged endometrium, which subsequently must continue to develop to accommodate the growing and maturing embryo and then fetus. This process is normally regulated by hormonal interactions between the fetal, endometrial and luteal tissue. It has been found that after IVF additional support for the endometrium with progesterone improves implantation and subsequent live birth rates in IVF cycle . Recent data has shown that additional supplementation with a single administration of a GnRH agonist around the time the time of embryo transfer may further enhance these rates .

Key facts

Study ID

NCT02357654

Run by

University Reproductive Associates

People needed

350

Starts

2015-11-01

Expected to finish

2026-07-01

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• women undergoing IVF/ICSI or frozen embryo transfers (FET) that less than 40 years old.

You may not qualify if…

• day 3 transfers

Where it is running

• University Reproductive Associates — Hasbrouck Heights, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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