Role of Cardiometabolic Risk Factors in Childhood Bone Development
Status unconfirmed
Conditions studied: Obesity, Cardiovascular Disease, Type 2 Diabetes, Osteoporosis
In brief
The proposed research brings together complementary expertise to systematically elucidate the longitudinal effects of (1) total and regional body fat and (2) the metabolic impairment that accompanies obesity on bone development during growth. The contribution of this research will be significant because it will provide a solid foundation for understanding the influence of fat (total and regional distribution) on overall bone strength, and whether insulin resistance, beta-cell dysfunction, abnormal lipids, and inflammation could be underpinning factors in the fat-bone strength relationship via effects on bone modeling activity. This knowledge will provide critical information needed to maximize potential therapeutic interventions to counter the linked risks of obesity and osteoporosis, both major public health concerns.
Key facts
- Study ID
- NCT02355717
- Run by
- Augusta University
- People needed
- 400
- Starts
- 2014-12-01
- Expected to finish
- 2021-12-30
- Last updated by the study team
- 2019-11-20
Who can join
Age: 9 and older, up to 15. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Otherwise healthy children and adolescents between 9 and 15 years old
- Subject and parent/guardian understands the study protocol and agrees to comply with it
- Informed Consent Form signed by the parent/guardian and assent signed by the subject
You may not qualify if…
- Subjects with (a history of) metabolic or gastrointestinal diseases including hepatic disorders
- Subjects presenting chronic degenerative and/or inflammatory diseases
- Subjects receiving systemic treatment or topical treatment likely to interfere with evaluation of the study parameters (salicylates, antibiotics)
- Subjects receiving corticosteroid treatment
- Subjects using oral anticoagulants
- Subjects who have participated in a clinical study more recently than one month before the current study
Where it is running
- Medical College of Georgia; Augusta University — Augusta, Georgia, United States (enrolling)
Full record on ClinicalTrials.gov
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