Genetically Informed Smoking Cessation Trial

Completed · Phase 4 · Has a placebo group

Conditions studied: Smoking Cessation

In brief

The investigators' goal is to identify the most appropriate smoking cessation treatments for smokers based on genetic information. Smokers try to quit smoking but relapses are common.

Key facts

Study ID

NCT02351167

Run by

Washington University School of Medicine

People needed

822

Starts

2015-05-20

Expected to finish

2019-08-31

Last updated by the study team

2020-09-22

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult (≥21 years of age), seeking treatment for smoking cessation.
• Able to speak English,
• Active smoking (Cigarettes Per Day (CPD) ≥5), and exhaled Carbon Monoxide (CO) ≥8 ppm
• Agree to participate in this randomized smoking cessation trial with follow up assessments up to 12 months.

You may not qualify if…

• Pregnancy or breast feeding,
• Active use or recent use (< or equal to 1 month) of medication or e-cigarettes for nicotine dependence/smoking cessation, or use of e-cigarettes for more than 9 days in the prior month,
• Allergy to nicotine patch, lozenge, or varenicline,
• Unwillingness to prevent pregnancy during the medication phase and 1 month afterwards (women only),
• Significant cardiac conditions (myocardial infarction, unstable angina, coronary angioplasty, cardiac bypass) or serious arrhythmia in past 6 months,
• Current heavy alcohol consumption (≥6 drinks/day, 6 days/week),
• Active psychosis or poorly controlled depression within the past 6 months,
• Any prior suicide attempt or suicidal ideation within the past 6 months,
• End stage renal disease with hemodialysis.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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