The Influence of Histo-blood Group Antigen Polymorphism on the Composition of the Microbiota

Withdrawn before enrolling

Conditions studied: Microbiota Analysis in Healthy Subjects

In brief

A person's blood type is defined by the types of sugars they express on their red blood cells, with antibodies being made to non-self sugars and excluding blood cells expressing these sugars (the basis of blood transfusion reactions). These same sugars can be expressed by commensal bacteria in our gut lumens. The investigators hypothesize that a person's antibodies to non-self sugars also attach to and exclude non-self sugar-expressing bacteria in our guts. Supporting our hypothesis, a person's blood type correlates with the overall composition of their gut flora. Because these sugars are also used by certain pathogens to initiate infection, this information could directly inform our understanding of host susceptibility to various infectious organisms.

Key facts

Study ID
NCT02349932
Run by
University of Florida
People needed
0
Starts
2019-07-01
Expected to finish
2023-01-01
Last updated by the study team
2019-08-13

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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