Antiviral Prophylaxis in a Burn Population

Withdrawn before enrolling · Phase 2/Phase 3

Conditions studied: Herpes Simplex

In brief

A prospective, randomized trial to calculate incidence of Herpes Simplex Virus in an in-patient burn population and determine efficacy of prophylactic antiviral therapy to prevent viral infection and/or reactivation. Hypothesis is that antiviral prophylaxis will be effective in reducing HSV infection/reactivation.

Key facts

Study ID: NCT02349828
Run by: Southern Illinois University
People needed: 0
Starts: 2015-09-01
Expected to finish: 2016-04-01
Last updated by the study team: 2016-04-21

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients presenting to Memorial Medical Center's Regional Burn Unit, both transfers and direct admissions
Patients aged 24 months to 110 years old
Patients presenting with thermal, flame, flash, chemical, grease or electrical burns
Patients with second degree or higher burn to the face or burn to any part of the body of 20% TBSA or greater
Patients, power of attorney or legally authorized representative cognitively competent to give consent.

You may not qualify if…

Patients who do not wish to consent to all facets of the study
Patients younger than 24 months
Patients older than 110 years of age
Patients with mechanical skin injury (ie, road rash, crush injury)
Patients who are pregnant or become pregnant during the treatment phase of the study
Patients with a documented allergy to Acyclovir, Famcyclovir or Valacyclovir
Patients already taking Acyclovir, Famcyclovir or Valacyclovir
Patients who have or develop thrombotic thrombocytopenic purpura
Patients have or develop hemolytic uremic syndrome
Patients concurrently taking Tizanidine, Phenytoin, Valproic Acid, Fosphenytoin, Meperidine, Micophenolic Acid, Tenofovir Disoproxil Fumarate, or Zidovudine
Patients whom the investigator feels would be inappropriate.

Where it is running

Southern Illinois University School of Medicine — Springfield, Illinois, United States

Full record on ClinicalTrials.gov

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