Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

Recruiting now · Phase 4

Conditions studied: Atrial Fibrillation

In brief

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will test the hypothesis that a common AF genetic risk allele modulates response to different AADs.

Key facts

Study ID

NCT02347111

Run by

University of Illinois at Chicago

People needed

162

Starts

2020-12-31

Expected to finish

2026-06-30

Last updated by the study team

2025-08-24

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 18 years of age
• History of typical or early-onset symptomatic (≥2 episodes/month) paroxysmal/persistent AF
• ECG that was recorded within 1 month of randomization showing AF
• Eligible for both Flecainide(Class I) and Sotalol (Class III) AAD
• Able to give informed consent

You may not qualify if…

• Permanent AF or isolated atrial flutter
• Cardiac or thoracic surgery within the previous 6 months
• Previous use of amiodarone other than short-term use (e.g. for an acute arrhythmia in hospital)
• Medical condition that is likely to be fatal in less than one year
• A history of prior AF ablation
• Have already been tried on 2 or more AADs in the past for AF
• Creatinine clearance <40 ml/min
• Left ventricular ejection fraction < 50%
• Contra-indication to a Class I AAD e.g., structural heart disease, or history of MI
• Contra-indication to a Class III AAD, e.g., congenital or acquired long QT syndrome with QTc>480 ms in females and >460 ms in males at baseline
• A reversible cause of AF (e.g., hyperthyroidism)
• Females who are pregnant or nursing
• History of severe AV node dysfunction unless an electronic pacemaker is present
• First- or second-degree relative has already participated in the study
• Unable to adhere to study procedures that are strictly for research purposes

Where it is running

• University of Illinois at Chicago — Chicago, Illinois, United States (enrolling)
• Jesse Brown VA Medical Center — Chicago, Illinois, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Advocate Christ Medical Center — Oak Lawn, Illinois, United States

Full record on ClinicalTrials.gov

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