Effects of Iron and/or Zinc Supplementation in Mexican School Children Exposed to Lead

Completed · Not applicable · Has a placebo group

Conditions studied: Lead Poisoning

In brief

Lead is negatively linked to nutritional status, behavior and cognition in children. Despite extensive knowledge of its toxicity and efforts to reduce exposure, lead continues to be a problem in developed and developing countries. When lead exposure is unavoidable due to its pervasive nature, effective means of protecting or disrupting that exposure need to be developed. Nutritional interventions are one such option. We conducted a 2x2 factorial, placebo-controlled trial of 6-month iron and zinc supplementation among lead-exposed children in Torreón, Mexico (altitude 1060 m). Nine schools were selected based on proximity to a lead smelter and first-graders were individually randomized to daily treatment with 30 mg iron, 30 mg zinc, both, or placebo. In addition to biochemical indicators, cognitive functions and behavior were evaluated at baseline, after the 6-month supplementation period, and again after another 6 months (without supplementation). At baseline, 602 children ages 6.2-8.5 years were enrolled.

Key facts

Study ID
NCT02346188
Run by
Johns Hopkins Bloomberg School of Public Health
People needed
602
Starts
2000-01-01
Expected to finish
2001-12-01
Last updated by the study team
2015-01-26

Who can join

Age: 6 and older, up to 8. Sex: any. Healthy volunteers: accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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