Phase 1b Study of CCX872-B in Patients With Pancreatic Adenocarcinoma

Completed · Phase 1

Conditions studied: Pancreatic Cancer

In brief

This is an open-label phase 1-b study to evaluate the safety and efficacy of CCX872-B in patients with pancreatic adenocarcinoma also receiving FOLFIRINOX chemotherapy.

Key facts

Study ID

NCT02345408

Run by

Amgen

People needed

54

Starts

2015-02-01

Expected to finish

2020-05-06

Last updated by the study team

2025-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed non-resectable pancreatic adenocarcinoma with or without metastases
• Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2
• Anticipated life expectancy ≥ 12 weeks
• Radiographically measurable disease acc. to RECIST 1.1
• Use of adequate contraception (as described in protocol)
• Ability to provide written informed consent and comply with study requirements

You may not qualify if…

• Received other cancer treatment or investigational drug within 4 weeks prior to screening
• Women who are pregnant or breastfeeding
• Had major surgery within 4 weeks of first dose of study drug
• Inadequate liver, renal or bone marrow function within 2 weeks of first dose
• Serious concurrent illness, altered medical status or any uncontrolled medical condition
• Any infection requiring antibiotic or anti-viral treatment within 4 weeks of screening
• Known active HIV, HBV or HCV infection
• Inability to swallow tablets
• History or presence of any medical condition or disease which, in the opinion of the investigator, may place the subject at unacceptable risk for study participation

Where it is running

• Study site — St Louis, Missouri, United States
• Study site — Rochester, New York, United States
• Study site — Amsterdam, Netherlands
• Study site — Nijmegen, Netherlands
• Netherland — Rotterdam, Netherlands
• Study site — Sittard, Netherlands

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.