Transcranial Alternating Current Stimulation for Major Depressive Disorder

Completed · Not applicable · Has a placebo group

Conditions studied: Major Depressive Disorder, MDD

In brief

Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on patients with Major Depressive Disorder (MDD).

Key facts

Study ID

NCT02339285

Run by

University of North Carolina, Chapel Hill

People needed

32

Starts

2015-05-07

Expected to finish

2017-06-19

Last updated by the study team

2018-08-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, 18-65 years old
• Diagnostic and Statistical Manual of Mental Disorder, 4th edition (DSM-IV) diagnosis of MDD; unipolar, non-psychotic
• Hamilton Depression Rating Scale score >8
• Capacity to understand all relevant risks and potential benefits of the study (informed consent)
• Meet criteria for low suicide risk
• Willing to comply with all study procedures and be available to do so for the duration of the study
• Women of reproductive potential must use highly effective contraception

You may not qualify if…

• DSM-IV diagnosis of alcohol of substance abuse (other than nicotine) within the last month or a DSM-IV diagnosis of alcohol or substance dependence (other than nicotine) within the last 6 months
• Current use of benzodiazepines or anti-epileptic drugs
• Current axis I mood, or psychotic disorder other than major depressive disorder
• Lifetime comorbid psychiatric bipolar or psychotic disorder
• Eating disorder (current or within the past 6 months)
• Obsessive-compulsive disorder (lifetime)
• Post traumatic stress disorder (PTSD; current or within the last 6 months)
• Attention Deficit Hyperactivity Disorder (ADHD; currently under treatment)
• Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
• Neurological disorders, including but not limited to history of seizures (except childhood febrile seizures and ECT induced seizures), dementia, history of stroke, Parkinson's disease, multiple sclerosis, cerebral aneurism
• Medical or neurological illness (unstable cardiac disease, AIDS, malignancy, liver or renal impairment) or treatment for a medical disorder that could interfere with study participation
• History of traumatic brain injury, reoccurring seizures or later cognitive rehabilitation, or causing cognitive sequelae
• Prior brain surgery
• Any brain devices/implants, including cochlear implants and aneurysm clips
• Co-morbid neurological condition (i.e. seizure disorder, brain tumor)
• Non English speakers
• Pregnancy, nursing, or if female and fertile, unwilling to use appropriate birth control measures during study participation

Where it is running

• UNC Chapel Hill Medical School Wing C — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.