Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Recruiting now

Conditions studied: Healthy Volunteers, Non-Healthy/Non-Frail, Frail

In brief

Background: \- Biomarkers are substances in people's blood and tissues. They help researchers understand diseases and signs of aging. Scientists want to do more research on biomarkers to find ways to improve quality of life in old age. Objective: \- To learn more about biomarkers and their relationship to aging. Eligibility: \- Adults at least 20 years old who weigh at least 110 pounds and have a body mass index below 30. They must agree that their genetic samples can be collected, studied, and stored. Design: * Participants will be screened with medical history, physical exam, EKG and blood and urine tests. * Participants will have 3-day visits. They will return every 2 years. * All visits include: * Blood and urine collection * Physical performance tests * Health questionnaires * Memory and problem-solving tests * Magnetic Resonance Imaging (MRI) and Computerized Tomography (CT) scans. * Muscle metabolism/ exercise tests * Taste strips * Muscle and/or skin biopsies/ red light therapy * Retinal imaging/ eye tracking * Sleep study * ODD visits also include: * Cytapheresis * Bone marrow aspirate * EVEN visits also include: * Hyperglycemic CLAMP * Lumbar Puncture (LP) * Continuous Glucose Monitor (CGM)

Key facts

Study ID

NCT02339012

Run by

National Institute on Aging (NIA)

People needed

900

Starts

2015-03-15

Expected to finish

2099-12-31

Last updated by the study team

2026-08-06

Who can join

Age: 20 and older, up to 120. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• HIV virus infection (all groups).
• Hepatitis B or C (all groups).
• Active syphilis, gonorrhea or TB requiring treatment (all groups).
• WBC <3,000 or > 12,000/k/microL (only Healthy group).
• Platelets < 100,000 or >600,000 k/ microL (only Healthy group).
• Hemoglobin < 11.0 gm/dL in women and < 12.0 gm/dL in men (only Healthy group).
• GFR <50 mL/min/1.73 m\^2 (only Healthy group)
• GFR <= to 30 (only non-Healthy-or-Frail group or Frail group)
• Bilirubin > 1.5 mg/dl (unless higher levels can be ascribed to Gilbert's disease (only Healthy group).
• ALT, AST, or alkaline phosphatase twice the normal serum concentration (only Healthy group).
• Corrected calcium < 8.5 or > 10.7 mg/dl (all groups).
• Albumin < 3.1 g/dl (only Healthy group).
• Cholesterol, LDL and/or Triglycerides >1.5x normal (only Healthy group).
• Positive Urine Drug Screen (unless taking prescribed medication and at the discretion of the PI) (all groups).
• Currently pregnant or a nursing mother (all groups).
• Furthermore, if the participant is found eligible at Screening and Baseline but fails a urine drug screen (unless taking a prescribed medication and at the discretion of the PI) at any of the subsequent visits, the participant will be asked to return to repeat the test and if positive, will no longer be eligible to participate in the study.

Where it is running

• National Institute of Aging, Clinical Research Unit — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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