Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
Running, not enrolling · Not applicable
Conditions studied: Frail Elderly, Coronary Artery Disease
In brief
Frailty is defined as a geriatric syndrome of impaired resiliency to stressors (such as cardiac surgery) that has been delineated recently in the cardiovascular literature. One of the most controversial areas of cardiac surgery has been whether off-pump coronary artery bypass grafting (OPCAB) surgery is superior to conventional on-pump coronary artery bypass grafting (CABG) surgery. There is an ongoing debate about the benefits and disadvantages of OPCAB surgery and we believe that this remains an important technique for the improvement of coronary surgery. The benefits of CABG surgery in frail patients are still undetermined. The aim of this study is to clarify the potential benefit of OPCAB surgery in pre-frail and frail patients by comparing off-pump versus on-pump CABG in these patients.
Key facts
- Study ID
- NCT02338947
- Run by
- University of Sao Paulo General Hospital
- People needed
- 440
- Starts
- 2019-01-01
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-03-05
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants aged ≥60 years with the indication of myocardial revascularization with ≥2 criteria of frailty by Fried Frailty Criteria, and suitable to undergo either Off-pump or On-pump CABG.
You may not qualify if…
- Patients with the indication of angioplasty or another procedure in addition to CABG; patients who underwent an emergency operation (within 24 hours after hospital admission); patients who underwent previous cardiac surgery, even with other approaches than median sternotomy; patients who do not have free, prior and informed consent to participate in this study.
Where it is running
- Emory University School of Medicine — Atlanta, Georgia, United States
- Hospital de Messejana — Fortaleza, Ceará, Brazil
- Hospital das Clínicas Samuel Libânio — Pouso Alegre, Minas Gerais, Brazil
- Hospital Alberto Urquiza Wanderley — João Pessoa, Paraíba, Brazil
- Instituto Nacional de Cardiologia de Laranjeiras — Rio de Janeiro, Rio de Janeiro, Brazil
- Beneficência Portuguesa de São Paulo — São Paulo, São Paulo, Brazil
- Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo — São Paulo, São Paulo, Brazil
Full record on ClinicalTrials.gov
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