Botanical Oils Study to Determine Genetic Differences in the Way Your Body Processes Fats in Edible Oils

Completed · Not applicable

Conditions studied: Genetic Differences of Lipid Metabolism/Healthy Subjects

In brief

A randomized, controlled, cross-over clinical trial of borage oil vs soybean oil to determine whether the metabolism and/or impact of medium chain-polyunsaturated fatty acids (MC-PUFAs) in botanical oil supplements are changed in relationship to specific genotypes in a SNP (rs174537) strongly associated with FADS1 activity and PUFA metabolism.

Key facts

Study ID

NCT02337231

Run by

Wake Forest University Health Sciences

People needed

66

Starts

2014-06-24

Expected to finish

2015-12-15

Last updated by the study team

2018-08-14

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to give informed consent
• Must agree to adhere to dietary requirements during the entire study
• Be willing to participate for the whole study
• Be willing to not take PUFA supplements outside of those provided by the study
• Agree not to take interfering medications during the duration of the study
• Agree to allow samples to be stored for future use

You may not qualify if…

• May not have diabetes, cancer, heart attack or vascular surgery within the past year, be diagnosed with heart disease, have uncontrolled high blood pressure, history of stroke, atherosclerosis, asthma, multiple sclerosis or chronic joint disease
• Gallbladder removal or gallbladder disease
• Use of tobacco products within the last six months
• Pregnancy or lactation
• Fasting triglycerides greater than 150 mg/dl
• Blood pressure greater than 130/90
• BMI equal to or greater than 30 or less than 19
• Fasting glucose greater than 125 mg/dl
• Have liver function values in the normal range
• Taking greater than 100 mg aspirin/day
• Taking NSAIDS or oral corticosteroids
• Taking montelukast-type allergy medications
• Having a pacemaker or a defibrillator
• Taking lipid lowering medications

Where it is running

• Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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