A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors
Completed · Phase 1/Phase 2
Conditions studied: Squamous Cell Carcinoma of the Head and Neck (SCCHN), Ovarian Carcinoma-Enrollment Completed, Colorectal Cancer (CRC)-Enrollment Completed, Renal Cell Carcinoma (RCC) (Phase ll Only), Glioblastoma (GBM) (Phase ll Only)-Enrollment Completed
In brief
This is a study to determine the clinical benefit (how well the drug works), safety, and tolerability of combining varlilumab and nivolumab (also known as Opdivo® , BMS-936558). Both drugs target the immune system and may act to promote anti-cancer effects.
Key facts
- Study ID
- NCT02335918
- Run by
- Celldex Therapeutics
- People needed
- 175
- Starts
- 2015-01-01
- Expected to finish
- 2018-12-12
- Last updated by the study team
- 2019-12-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Arizona Cancer Center — Tucson, Arizona, United States
- The Stanford Center for Clinical and Translational Education and Research — Palo Alto, California, United States
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- University of Colorado Medical Center — Aurora, Colorado, United States
- Smilow Cancer Hospital at Yale University Cancer Center — New Haven, Connecticut, United States
- Georgetown University — Washington D.C., District of Columbia, United States
- George Washington University School of Medicine and Health Sciences — Washington D.C., District of Columbia, United States
- Mount Sinai Medical Center — Miami Beach, Florida, United States
- Northwest Georgia Oncology Centers PC — Marietta, Georgia, United States
- Parkview Research Center — Fort Wayne, Indiana, United States
- Dana Farber Cancer Institute — Boston, Massachusetts, United States
- Barbara Ann Karmanos Cancer Institute — Detroit, Michigan, United States
- Laura and Isaac Perlmutter Cancer Center — New York, New York, United States
- Columbia University Medical Center — New York, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Wake Forest Baptist Health — Winston-Salem, North Carolina, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- Providence Health & Services — Portland, Oregon, United States
- Inova Schar Cancer Institute Research — Fairfax, Virginia, United States
Full record on ClinicalTrials.gov
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