The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults

Completed · Not applicable

Conditions studied: Impairment of Oral Perception, Insulin Resistance

In brief

The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adults. The investigators hypothesize that dietary exposure to artificial sweeteners (sucralose) will decrease sensitivity to taste, shift preference of sweet and savory taste to a higher dose, and reduce brain response in amygdala to sweet taste compared to sucrose.

Key facts

Study ID

NCT02335021

Run by

Yale University

People needed

97

Starts

2015-01-01

Expected to finish

2019-04-24

Last updated by the study team

2019-09-26

Who can join

Age: 23 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• Fluent in English
• Right handed

You may not qualify if…

• History of oral nerve damage,
• presence of known taste or smell disorder,
• food allergies or sensitivities (for example nuts, lactose, artificial sweeteners),
• history of CNS disease,
• diabetes,
• history of DSM-IV major psychiatric disorder,
• including alcohol and substance abuse,
• chronic use of medication that may affect taste,
• conditions that may interfere with gustatory or olfactory perception (colds, seasonal allergies,
• recent smoking history),
• aberrant stimulus ratings,
• contra-indication for fMRI,
• uncomfortable swallowing in supine position,
• discomfort or anxiety associated with insertion an intravenous catheter,
• regular artificial sweetener use.

Where it is running

• Yale University — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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