The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity and Preference - Pilot

Completed · Not applicable

Conditions studied: Impairment of Oral Perception

In brief

The goal of this study is to test the hypothesis that repeated consumption of artificial sweetener reduces sweet taste intensity.

Key facts

Study ID

NCT02335008

Run by

Yale University

People needed

30

Starts

2014-09-01

Expected to finish

2015-07-01

Last updated by the study team

2015-07-15

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• Fluent in English

You may not qualify if…

• History of oral nerve damage,
• presence of known taste or smell disorder,
• food allergies or sensitivities (for example nuts, lactose, artificial sweeteners),
• history of CNS disease,
• diabetes,
• history of DSM-IV major psychiatric disorder, including alcohol and substance abuse, chronic use of medication that may affect taste,
• conditions that may interfere with gustatory or olfactory perception (colds, seasonal allergies, recent smoking history),
• aberrant stimulus ratings,
• contra-indication for fMRI,
• uncomfortable swallowing in supine position.

Where it is running

• The John B Pierce Laboratory — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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