Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

Completed · Not applicable

Conditions studied: Older Adults, Aging Brain

In brief

The primary objective of this study is to evaluate the effects of the experimental treatment (cognitive training) further outlined in this protocol on the cognitive abilities (e.g., processing speed, attention, working memory, and executive function), brain functionality, functional status and quality of life of individuals with age-related cognitive decline as compared to a computer-based active control.

Key facts

Study ID

NCT02331784

Run by

Posit Science Corporation

People needed

68

Starts

2015-04-01

Expected to finish

2017-04-20

Last updated by the study team

2019-04-19

Who can join

Age: 65 and older, up to 79. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 65-79 years at the time of consent
• Fluent English speakers, to ensure reasonable results neuropsychological assessments
• Adequate sensorimotor capacity to perform the program, including visual capacity adequate to read from a computer screen at a normal viewing distance, auditory capacity adequate to understand normal speech, and motor capacity adequate to control a computer mouse
• No evidence of dementia as indicated by Montreal Cognitive Assessment (MoCA) scores >25

You may not qualify if…

• Diagnosis with Alzheimer's disease or related dementias
• Requiring caregiver assistance in dressing/personal hygiene
• Medical conditions predisposing to imminent functional decline
• Recent participation of computer-delivered cognitive training
• Diagnosis of an illness or condition with known cognitive consequences (e.g., schizophrenia, bipolar disorder, cancer, multiple sclerosis) will be excluded due to the confound with cognitive impairment from normal aging.
• Uncorrectable acuity greater than 20/40
• Self-reported cardiovascular disease
• Claustrophobia or any other contraindication to MRI scanning
• Inability to complete a 1-hour MRI
• Any implanted devices above the waist (e.g., cardiac pacemaker or auto-defibrillators, neural pacemaker, aneurysm clips, cochlear implant, metallic bodies in the eye or central nervous system, any form of wires or metal devices that may concentrate radio frequency fields)
• History of brain surgery; removal of brain tissue; or history of stroke.

Where it is running

• University of Iowa — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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