Effects of tDCS and tUS on Pain Perception in OA of the Knee
Completed · Not applicable · Has a placebo group
Conditions studied: Chronic Pain, Osteoarthritis
In brief
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with osteoarthritis of the knee. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.
Key facts
- Study ID
- NCT02330315
- Run by
- Spaulding Rehabilitation Hospital
- People needed
- 28
- Starts
- 2015-03-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2020-04-24
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Able to provide informed consent to participate in the study.
- Subjects between 18-85 years old.
- Diagnosis of chronic osteoarthritis with pain of either the knee as self-reported.
- Prior to beginning baseline procedures this must be confirmed by medical records or a letter from the subject's physician. This document may either be brought in by the subject or retrieved by study staff after a medical release form is signed by the subject. After consent, if the subject fails to provide the necessary documentation or it cannot be retrieved by study staff the subject will be considered a screen fail.
- Existing knee pain in the past 6 months of at least 3 on a 0-10 VAS scale on average.
- Pain resistant to common analgesics and medications for chronic pain used as initial pain management such as Tylenol, Aspirin, Ibuprofen, Soma, Parafon Forte DCS, Zanaflex, and Codeine.
- Having the ability to feel pain as self-reported
You may not qualify if…
- Pregnancy or trying to become pregnant in the next 6 months.
- History of alcohol or drug abuse within the past 6 months as self-reported.
- Contraindications to transcranial brain stimulation or TUS, i.e. implanted brain medical devices or implanted brain metallic devices.
- Unstable medical conditions (e.g. uncontrolled diabetes, uncompensated cardiac issues, heart failure or chronic obstructive pulmonary disease).
- Epilepsy.
- Use of carbamazepine within the past 6 months as self-reported.
- Suffering from severe depression (with a score of >30 in the Beck Depression Inventory)
- History of unexplained fainting spells as self-reported.
- Head injury resulting in more than a momentary loss of consciousness
- History of neurosurgery as self-reported.
Where it is running
- Spaulding Rehabilitation Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.