Determination of the Predictors of Nocturnal Desaturation in Postpartum Women

Completed · Not applicable

Conditions studied: Sleep Disordered Breathing, Nocturnal Oxygen Desaturation, Upper Airway Edema

In brief

The primary aim of the study is to evaluate the effect of the method of delivery (vaginal delivery vs. cesarean section) on oxygen saturation in the first postpartum night. The investigators hypothesize that nocturnal desaturation occurs more frequently in cesarean section compared with vaginal delivery, expressed as either the duration of SpO2 below 90% or the Oxygen Desaturation Index (ODI). The ODI is defined as number of oxygen desaturations by at least 3 % per hour. Furthermore, the investigators expect a higher pulse rate and a lower mean and minimum SpO2 in the cesarean section group compared with the vaginal delivery group. The secondary aim of the study is to investigate how the upper body position during sleep (45 degree elevated vs. non-elevated) affects the oxygen saturation during the first postpartum night. The investigators hypothesize that an upper body elevation to 45 degrees decreases the incidence of desaturation events, expressed as either the duration of SpO2 below 90% or the ODI , compared with a non-elevated body position within each delivery group (vaginal delivery or cesarean section). The third aim of the study is to identify independent predictors of nocturnal desaturation in postpartum women. To that end, the investigators will administer questionnaires and collect demographic and clinical data according to various obstructive sleep apnea screening scores, including the P-SAP, STOP-Bang, and Epworth Sleepiness Scale. The investigators will also ask the patient to rate the pain during the study night on a verbal numerical rating scale.

Key facts

Study ID
NCT02330055
Run by
Massachusetts General Hospital
People needed
99
Starts
2014-05-01
Expected to finish
2017-12-01
Last updated by the study team
2018-07-06

Who can join

Age: 18 and older, up to 55. Sex: female. Healthy volunteers: not accepted.

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You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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