FLT PET/MR for Evaluation of Pseudoprogression in Patients With Brain Lesions

Withdrawn before enrolling

Conditions studied: Brain Lesions, Brain Metastasis, Brain Metastases

In brief

This is a single arm, single center study of 15 patients with brain lesions being treated at UNC Hospitals. Subjects will undergo one (1) FLT-PET-MRI scan before their scheduled surgical biopsy of their brain lesion(s).

Key facts

Study ID

NCT02328300

Run by

UNC Lineberger Comprehensive Cancer Center

People needed

0

Starts

2014-05-07

Expected to finish

2018-07-31

Last updated by the study team

2018-11-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Known brain lesion in central nervous system (CNS) scheduled to have surgical biopsy of the lesion, identified by the UNC Brain Tumor Board as having clinical question of radiation necrosis vs. recurrence
• At least one measurable lesion greater than 1 cm in diameter
• ≥ 18 years of age
• Study-specific informed consent reviewed and signed

You may not qualify if…

• Pregnant, nursing, or planning to become pregnant within 30 days of anticipated PET-MRI scan
• Condition that makes MRI unsafe (e.g., cardiac pacemaker, epicardial pacemaker leads, cochlear implants, metal aneurysm clips, metal halo devices)
• Inability to tolerate MRI (e.g., unable to lie flat for > 1 hour, severe claustrophobia)
• Allergy to MRI contrast agent (Magnevist, Multihance, Ablavar, Dotarem, Eovist, Gadavist)
• Known allergy to fluorothymidine
• Study participation would cause significant delay (> 2 weeks) in scheduled standard of care therapy
• Creatinine clearance < 60 ml/min, as estimated by the Cockcroft-Gault formula
• Body Mass Index (BMI) > 35
• Poorly controlled diabetes mellitus (fasting blood glucose > 200 mg/dl)

Where it is running

• University of North Carolina-Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.