Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Running, not enrolling

Conditions studied: Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Progressive Muscular Atrophy, Multisystem Proteinopathy

In brief

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Key facts

Study ID

NCT02327845

Run by

University of Miami

People needed

708

Starts

2015-04-01

Expected to finish

2031-08-01

Last updated by the study team

2026-06-15

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Member of at least one of the following categories:
• Individuals with a clinical diagnosis of ALS or a related disorder, including FTD, HSP, PLS, PMA and MSP (sporadic or familial).
• Family member of an enrolled affected individual.
• Able and willing to comply with relevant procedures.

You may not qualify if…

• Affected with end or late stage disease.
• A condition or situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol. This includes (but is not limited to) neurological, psychological and/or medical conditions.

Where it is running

• Stanford University — Palo Alto, California, United States
• University of California San Diego (UCSD) — San Diego, California, United States
• California Pacific Medical Center (CPMC) — San Francisco, California, United States
• University of Miami — Miami, Florida, United States
• University of Iowa — Iowa City, Iowa, United States
• Kansas University Medical Center (KUMC) — Kansas City, Kansas, United States
• Twin Cities ALS Research Consortium — Minneapolis, Minnesota, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Texas Southwestern (UTSW) — Dallas, Texas, United States
• University of Texas Health Science Center San Antonio (UTHSCSA) — San Antonio, Texas, United States
• University of Virginia (UVA) — Charlottesville, Virginia, United States
• Eberhard Karls University of Tübingen — Tübingen, Germany
• University of Cape Town — Cape Town, South Africa

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.