Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients
Completed · Not applicable
Conditions studied: Type 2 Diabetes Mellitus
In brief
Specific Aim 1.To examine whether the combination of liraglutide plus canagliflozin can prevent the increase in Hepatic Glucose Production (HGP) following institution of canagliflozin therapy and produce an additive or even synergistic effect to lower the plasma glucose concentration and A1c. Specific Aim 2: To examine whether combination therapy with liraglutide plus canagliflozin can produce an additive, or even synergistic, effect to promote weight loss and reduction in hepatic and visceral fat content. Specific Aim 3. To examine whether combination therapy with liraglutide plus canagliflozin can produce an additive or even synergistic effect to reduce systolic/diastolic blood pressure and 24-hour integrated blood pressure.
Key facts
- Study ID
- NCT02324842
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 45
- Starts
- 2014-11-01
- Expected to finish
- 2019-03-31
- Last updated by the study team
- 2019-12-18
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female subjects between the ages of 18-70
- Subjects with Type 2 Diabetes Mellitus (T2DM)
- Drug naïve or on stable dose (more than 3 months) of metformin with or without sulfonylurea
- Have an HbA1c levels ≥7.0% and <10.0%
- Stable weight (± 3 lbs) over the preceding 3 months
You may not qualify if…
- Subjects taking drugs known to affect glucose metabolism (other than metformin) will be excluded.
- Individuals with evidence of proliferative diabetic retinopathy or plasma creatinine >1.4 females or >1.5 males or estimated Glomerular Filtration Rate (eGFR)< 60 ml/min.172m2 will be excluded
- Unstable body weight (change of greater than ±3 lbs over the preceding 3 months)
- Participates in excessively heavy exercise program
Where it is running
- University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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