Use of EndoPAT for Measurements of Endothelial Dysfunction in HIV Infected Children and Healthy Controls

Completed

Conditions studied: HIV, Endothelial Dysfunction

In brief

Our objective is to determine whether HIV infected youth have higher level of endothelial dysfunction, as measured by Peripheral Arterial Tonometry, when compared to age matched healthy controls. The investigators also aim to gather preliminary data on whether endothelial Peripheral Arterial Tonometry (endoPAT) measurements of endothelial dysfunction are independently associated with HIV and antiretroviral factors, and with markers of inflammation and traditional cardiovascular disease risk.

Key facts

Study ID

NCT02324179

Run by

University Hospitals Cleveland Medical Center

People needed

76

Starts

2014-08-01

Expected to finish

2015-02-01

Last updated by the study team

2015-03-09

Who can join

Age: 8 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For HIV+ group:
• age 8-30 years of age
• HIV infection
• On continuous ART for at least 6 months
• HIV-1 RNA < 1,000 copies/mL performed in the past 5 months
• For healthy controls:
• age and gender matched 1:1 to HIV-positive subjects
• absence of known HIV or other medical conditions that may affect systemic inflammation
• Not receiving or prescribed any regular chronic medications.

You may not qualify if…

• - Active illness or regular medication
• Diabetes
• Known coronary artery disease
• Pregnancy and or lactation

Where it is running

• Special Immunology Unit — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.