An fMRI Study on Temporal Discounting in Bipolar Disorder

Completed

Conditions studied: Bipolar Disorder, Suicidal Ideation, Depression

In brief

The investigators propose to explore the link between bipolar disorder, anxiety, and suicide by investigating intertemporal discounting in depressed, suicidal patients with bipolar I and II disorder who have various levels of anxiety. The investigators will determine the effect of anxiety on their intertemporal discounting (small rewards now compared to larger rewards later) in a decision-making paradigm and investigate the associated functional neuroanatomy using functional magnetic resonance imaging (fMRI).

Key facts

Study ID

NCT02323763

Run by

Massachusetts General Hospital

People needed

28

Starts

2014-07-14

Expected to finish

2016-08-29

Last updated by the study team

2017-02-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets DSM-IV criteria for BD I and II current depressive episode
• Able to give written informed consent
• Age > to 18 years and < 65 years
• Currently suicidal as defined by a MADRS suicide item score of > 3 or previous history of serious suicidal ideation that required hospitalization.
• All subjects need to have normal hearing and normal/corrected-to-normal vision.

You may not qualify if…

• Medical illness or non-psychiatric medical treatment that would likely interfere with study participation
• Neurologic disorder, previous ECT, or history of head trauma (i.e. known structural brain lesion potentially confounding MRI results)
• Substance abuse within the past 3 months or current substance dependence (confirmed by MINI)
• Left-handedness
• Contraindications to MRI (metallic implants, claustrophobia, etc.)
• Subjects who need urgent psychiatric care requiring hospitalization (evaluated by clinicians).

Where it is running

• Bipolar Clinic and Research Program at Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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