A Study of LY3202626 in Healthy Participants and Participants With Alzheimer's Disease
Completed · Phase 1 · Has a placebo group
Conditions studied: Healthy Volunteers, Alzheimer Disease
In brief
This study involves single and multiple doses of LY3202626 and will evaluate the effects of LY3202626 on the body. There will be 4 parts to this study. In Parts A and B, single increasing doses of LY3202626 will be given in capsule form. Part A will also include itraconazole given orally as a solution. Part A will last approximately 8-12 weeks. Part B will last approximately 5-6 weeks. In Parts C and D, participants will be dosed multiple days with the study drug. Part C will last approximately 11-14 weeks. Part D will last approximately 11-14 weeks and participants must have Alzheimer's Disease. Participants may only enroll in one part.
Key facts
- Study ID
- NCT02323334
- Run by
- Eli Lilly and Company
- People needed
- 94
- Starts
- 2014-12-01
- Expected to finish
- 2016-02-01
- Last updated by the study team
- 2021-04-19
Who can join
Age: 20 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For Parts A, B, and C, are overtly healthy males or females (nonchildbearing potential), as determined by medical history and physical examination
- Have a body mass index (BMI) of 18 to 32 kilograms per square meter (kg/m\^2)
- For Part D, present with Mild Cognitive Impairment (MCI) due to Alzheimer's Disease (AD) or mild to moderate AD
- Have venous access sufficient to allow for blood sampling
- Are reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures and research unit policies
You may not qualify if…
- Taking over-the-counter or prescription medication with the exception of vitamins or minerals
- Smoke more than 10 cigarettes per day
- Are unwilling or unable to refrain from eating any food or drinking any beverage containing grapefruit or grapefruit juice for at least 2 weeks prior to first dose until completion of the study
Where it is running
- California Clinical Trials Medical Group — Glendale, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.