Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing

Completed · Phase 4

Conditions studied: Acetaminophen Toxicity

In brief

A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the toxic metabolites of acetaminophen.

Key facts

Study ID

NCT02322879

Run by

Beth Israel Deaconess Medical Center

People needed

21

Starts

2013-05-01

Expected to finish

2016-12-01

Last updated by the study team

2017-09-01

Who can join

Age: 20 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers ages 20-40
• Patients not taking any chronic medications

You may not qualify if…

• Any history of liver disease
• Frequent alcohol use (2 or more drinks more than 4 times per week)
• Pregnant women
• Chronic medical condition requiring daily pharmacotherapy or the use of any daily prescription medications.
• Unable to provide informed consent

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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