Effect of Brown Rice on the Risk Factors for Metabolic Syndrome
Completed · Not applicable
Conditions studied: Metabolic Syndrome
In brief
The purpose of the study is to determine the effect of consumption of brown rice on the risk factors of metabolic syndrome (MetS) as compared to consumption of white rice. Brown and white rice will be provided in the form of rice cakes and 100g will be consumed per day for 5 weeks each. The investigators hypothesize that brown rice will have beneficial effects as it is rich in fiber and also phytochemicals.
Key facts
- Study ID
- NCT02321553
- Run by
- Tufts University
- People needed
- 7
- Starts
- 2014-04-01
- Expected to finish
- 2015-02-01
- Last updated by the study team
- 2015-05-14
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men \& postmenopausal women, aged >50 years
- BMI >30 kg/m2 and/or waist/hip ratio >0.9 for men, >0.85 for women
- plus any two of the following four MetS factors
- Fasting plasma TG: 150-400 mg/dL (1.7 - 4.52 mmol/L)
- Fasting plasma HDL cholesterol: <40 mg /dL (1.03 mmol/L) for men, <50 mg/dL (1.29 mmol/L) for women
- Blood pressure: SBP, 130-160 mmHg and/or DBP 85-95 mmHg
- Fasting plasma glucose: fasting blood glucose 100-125 mg/dL (5.55- 6.94 mmol/L) and no medication for blood glucose regulation and no use of insulin
You may not qualify if…
- Cigarette smoking and/or nicotine replacement use
- Individuals taking estrogen
- Use of blood glucose lowering medications or insulin
- Regular use (>2x/wk) of any stomach acid-lowering medications or laxatives
- Regular use (>2x/wk) of medication for inflammation
- Regular use of medication for hypercoagulation
- Cardiovascular (heart) disease
- Gastrointestinal disease
- Renal or chronic kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure >160 mmHg and/or diastolic blood pressure >95 mmHg
- Regular use of oral steroids except topical OTC steroids
- Regular daily intake of ≥2 alcoholic drinks
- Infrequent (<3/wk) or excessive (>3/d) number of regular bowel movements
- Illicit drug use
- Vegetarians
- No fish oil supplements (including cod liver oil) for one month prior to study admission
- No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission
- On or planning a weight reducing regimen using a dietary approach of dietary supplements
Where it is running
- Clinical and Translation Research Center, Tufts Medical Center — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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