ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

Completed · Phase 3

Conditions studied: Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC), Amyloidosis, Hereditary, Amyloid Neuropathies, Familial, Amyloid Neuropathies, Amyloidosis, Hereditary, Transthyretin-Related, Familial Transthyretin Cardiac Amyloidosis

In brief

The purpose of this study was to evaluate the safety and efficacy of revusiran (ALN-TTRSC) in patients with transthyretin (TTR) mediated Familial Amyloidotic Cardiomyopathy. Dosing has been discontinued; patients are being followed-up for safety.

Key facts

Study ID

NCT02319005

Run by

Alnylam Pharmaceuticals

People needed

206

Starts

2014-12-01

Expected to finish

2017-03-30

Last updated by the study team

2018-07-18

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Documented TTR mutation
• Amyloid deposits in cardiac or non-cardiac tissue
• Medical history of heart failure
• Evidence of cardiac involvement by echocardiogram

You may not qualify if…

• Has known primary amyloidosis (AL), leptomeningeal amyloidosis, non-FAC hereditary cardiomyopathy, hypertensive cardiomyopathy, or cardiomyopathy due to valvular heart disease
• Has known peripheral vascular disease affecting ambulation
• Has a Polyneuropathy Disability score >2
• Has a New York Heart Association (NYHA) classification of IV

Where it is running

• Clinical Trial Site — Beverly Hills, California, United States
• Clinical Trial Site — La Mesa, California, United States
• Clinical Trial Site — Los Angeles, California, United States
• Clinical Trial Site — San Francisco, California, United States
• Clinical Trial Site — Stanford, California, United States
• Clinical Trial Site — Torrance, California, United States
• Clinical Trial Site — Aurora, Colorado, United States
• Clinical Trial Site — Washington D.C., District of Columbia, United States
• Clinical Trial Site — Washington D.C., District of Columbia, United States
• Clinical Trial Site — Tampa, Florida, United States
• Clinical Trial Site — Atlanta, Georgia, United States
• Clinical Trial Site — Chicago, Illinois, United States
• Clinical Trial Site — Chicago, Illinois, United States
• Clinical Trial Site — Chicago, Illinois, United States
• Clinical Trial Site — New Orleans, Louisiana, United States
• Clinical Trial Site — Baltimore, Maryland, United States
• Clinical Trial Site — Baltimore, Maryland, United States
• Clinical Trial Site — Boston, Massachusetts, United States
• Clinical Trial Site — Boston, Massachusetts, United States
• Clinical Trial Site — Boston, Massachusetts, United States
• Clinical Trial Site — Detroit, Michigan, United States
• Clinical Trial Site — Rochester, Minnesota, United States
• Clinical Trial Site — St Louis, Missouri, United States
• Clinical Trial Site — Newark, New Jersey, United States
• Clinical Trial Site — Bakersfield, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.