Assessment of Esophageal Epithelium Integrity With Mucosal Impedance

Completed · Not applicable

Conditions studied: Gastroesophageal Reflux Disease (GERD), Non-erosive Reflux Disease (NERD)

In brief

Gastroesophageal reflux disease (GERD) is a common condition affecting more than 100 million adults in the U.S., and it significantly impacts patients' quality of life while imposing billions of dollars of direct and indirect costs each year upon our healthcare system. Current diagnostic tests for GERD are highly invasive and medically inadequate, and the goal of this project is to develop a novel, minimally invasive Mucosal Impedance technique for more accurate detection of GERD while reducing costs.

Key facts

Study ID

NCT02318862

Run by

Vanderbilt University Medical Center

People needed

15

Starts

2013-07-01

Expected to finish

2016-12-01

Last updated by the study team

2026-05-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing standard of care EGD with 48-hr pH testing by BRAVO
• Previous diagnosis of reflux
• At least 18 years of age

You may not qualify if…

• Those less than 18 years of age
• Unable to give informed consent
• Use of acid suppressive therapy within the last 10 days
• Known history of Barrett's esophagus, gastric surgery, alcoholism, or significant motility condition

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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