Intra-Articular Dexamethasone to Prevent Post-Traumatic Osteoarthritis: A Pilot Study

Completed · Early Phase 1

Conditions studied: Distal Radius Fracture, Osteoarthritis

In brief

The primary aim of the study is to see if a single wrist injection (intra-articular) of dexamethasone at the time of treatment will reduce the incidence of early-onset of post traumatic osteoarthritis.

Key facts

Study ID

NCT02318433

Run by

Mayo Clinic

People needed

43

Starts

2014-12-01

Expected to finish

2019-07-19

Last updated by the study team

2020-04-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unstable distal radius fracture
• Fracture type AO B1, B2, B3, C1, C2 or C3.
• 18-65 years old
• Understand and read English
• Community dwelling (not in assisted living or NH)

You may not qualify if…

• Open or bilateral DRF
• Associated upper extremity carpal fracture or carpal ligament injuries requiring casting or surgical repair at the time of DRF fixation.
• Greater than 2 weeks post injury
• Neurologic disorders affecting the hand, wrist or arm.
• History of permanent dementia, Alzheimer's or other neurologic dx
• Substance abuse
• Pathologic fractures
• Known pregnancy
• Radiocarpal joint arthritis

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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