Exercise and Genes in Obese (EGO)

Status unconfirmed · Not applicable

Conditions studied: Obesity

In brief

Regular exercise has several positive health effects including increased physical fitness and muscle mass. It is well known that increased muscle mass is associated with increased resting energy expenditure which may facilitate weight loss and maintenance. Previous studies have, however, failed to show any consistent association between the intensity of physical exercise and energy expenditure, or relate the variance in these adaptations to genetic variability. Whether high-intensity exercise (HIE) is associated with improved health related quality of life in severely obese patients remains unknown. This PhD-project is based on a planned randomised controlled study including 50 or more treatment seeking morbidly obese patients who will be randomised to either a 24 week moderate-intensity exercise (MIE) programme or a 24 week high-intensity exercise (HIE) programme. The investigators main hypothesis is that patients randomised to the HIE-program will achieve higher energy expenditure during rest and physical activity after treatment than those allocated to the MIE-programme. In addition, the investigators hypothesise that the HIE-group will achieve a better health related quality of life than the MIE-group after treatment. The investigators also hypothesize that inter-individual variability in adaptation to the two training regimens may be due to genetic factors. If the investigators hypotheses are confirmed, this project might have beneficial clinical implications for future obesity treatment strategies.

Key facts

Study ID

NCT02311738

Run by

Jarle Berge

People needed

50

Starts

2015-01-01

Expected to finish

2023-08-01

Last updated by the study team

2021-09-23

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Treatment seeking weight stable morbidly obese patients (BMI ≥ 40 kg/m2 or BMI 35 to 39.9 kg/m2 with ≥ 1 co morbidity) attending the outpatient Obesity Center, Vestfold Hospital Trust, will be informed about this RCT .

You may not qualify if…

• Uncompensated heart failure
• Recent myocardial infarction or stroke (<½ years)
• Severe arrhythmia or heart failure
• Unstable angina pectoris
• Renal failure
• Pregnancy
• Severe eating disorders
• Active substance abuse
• Being on a diet
• Taking medication known to affect appetite or metabolism (including thyroxin).

Where it is running

• Duke University School of Medicine — Durham, North Carolina, United States
• Vestfold University College — Horten, Raveien, Norway
• Telemark University College — Bø, Norway
• University in Agder — Kristiansand, Norway
• Norges Teknisk-naturvitenskapelig Universitet — Trondheim, Norway
• Vestfold Hospital Trust — Tønsberg, Norway

Full record on ClinicalTrials.gov

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