Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes
Status unconfirmed · Not applicable
Conditions studied: Disuse Osteoporosis, Atrophy, Disuse, Nervous System, Structural; Marker, Skeletal Muscle Hypertrophy
In brief
For many after spinal cord injury (SCI) there is immobilization, muscle atrophy, bone loss, fracture risk during transferring (or falls), and the risk of secondary complications, and increase in attendance care and cost. It is important to develop multi dimensional rehabilitation strategies for people after SCI to enhance functional recovery towards walking, and enhance an increase in muscle and bone to potentially prepare the injured nervous system in the event of a cure. Locomotor training (Stand retraining and step re training) an activity-based rehabilitative approach generates muscle activity and provides weight bearing and joint contact kinetics, even in individuals who are unable to stand or step independently. Cross-sectional animal and human SCI studies have demonstrated that locomotor training (LT) (stand retraining and step retraining using body weight support treadmill training) has improved the capacity to stand independently and walk at faster speeds. Neuromuscular stimulation (NMS) or electrical stimulation (ES) training is a rehabilitative approach that generates muscle activity, alternating leg extension and flexion even in individuals who are unable to stand or step independently. NMS studies for individuals after SCI have shown improvements in bone density and muscle strength after cycling and resistance training. The main purpose of this study is to address whether stand retraining and NMS compared to stand retraining alone or NMS alone will increase neural and musculoskeletal gains and provide a greater functional recovery towards independent standing. This project will be completed at two sites: Kessler Foundation Research Center (the grant PI site) and Frazier Rehabilitation Institute, University of Louisville, Kentucky.
Key facts
- Study ID
- NCT02309983
- Run by
- Kessler Foundation
- People needed
- 21
- Starts
- 2006-12-01
- Expected to finish
- 2018-12-01
- Last updated by the study team
- 2017-03-28
Who can join
Age: 18 and older, up to 58. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Must be between 18 and 58 years old with a neurological SCI level between the C6-T10 level and an impairment grade A, B, or C, according to the American Spinal Injury Association (ASIA) Impairment scale.
- Must have a spinal cord injury that is greater than 6 month or less than 2 years post injury
- Must have score less than 3 on the Modified Ashworth Scale.
- Must be able to tolerate electrical stimulation and must show visible muscle contraction to electrical stimulus
- Must be wheelchair reliant for more than 75% of the time
You may not qualify if…
- Bone density measurement (as recorded by the researcher) for knee at or below 0.5755 gm/cm2
- Weigh more than 225 Ibs.
- Taller than 6 feet 3 inches
- Post -menopausal, pregnant or a lactating woman.
Where it is running
- Kessler Foundation — West Orange, New Jersey, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.