Pancreatic Cancer Screening of High-Risk Individuals in Arkansas

Withdrawn before enrolling · Not applicable

Conditions studied: Pancreatic Neoplasms, Peutz-Jegher's Syndrome, BRCA1 Gene Mutation, BRCA2 Gene Mutation, Ataxia Telangiectasia, Familial Atypical Mole-Malignant Melanoma Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Pancreatitis

In brief

100 subjects who have a family history of pancreatic cancer (PC), or known genetic syndromes associated with increased risk of pancreatic cancer, will be followed for five years. This data will be used to determine the pancreatic cancer and precancerous lesion detection rate in High Risk Individuals (HRIs). Subjects may agree to annual imaging and annual biomarkers or to biomarkers only.

Key facts

Study ID

NCT02309632

Run by

University of Arkansas

People needed

0

Starts

2015-11-01

Expected to finish

2019-07-19

Last updated by the study team

2019-07-29

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a family history of PC as listed below or who have one of the following syndromes: Peutz-Jeghers syndrome - STK11; BRCA 1 and 2; PALB2; ATM; FAMMM / P16; HNPCC (Lynch) / MMR genes; Hereditary pancreatitis - PRSS1
• Individuals with three or more affected blood relatives (1st, 2nd or 3rd degree)
• Individuals with two or more affected blood relatives with PC, with at least one affected FDR, should be considered for screening.
• Patients with a history of Peutz-Jeghers syndrome should be screened, regardless of family history of PC.
• Patients with a known p16 (FAMMM syndrome) with one affected 1st or 2nd degree relative will be considered for screening.
• Patients with a known BRCA1 or BRCA2 mutation with one affected 1st or 2nd degree relative should be considered for screening.
• Patients with a known PALB2 mutation with one affected family member should be considered for screening.
• Patients with a known Mismatch-repair gene-mutation carriers (Lynch syndrome) with one affected family member should be considered for screening.

You may not qualify if…

• Not candidates for surgery

Where it is running

• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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