Myocardial Stress Perfusion Computed Tomography in the Evaluation of Patients With Acute Chest Pain Using a Novel 3rd Generation Dual-source CT System

Stopped early · Not applicable

Conditions studied: Chest Pain

In brief

To assess the ability of a novel 3rd generation dual-source CT system to demonstrate myocardial perfusion in a cohort of patients presenting to the Chest Pain Center with acute chest pain.

Key facts

Study ID

NCT02308475

Run by

Medical University of South Carolina

People needed

2

Starts

2014-12-01

Expected to finish

2015-07-06

Last updated by the study team

2018-07-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject must present with symptoms of acute but atypical or recurrent chest pain.
• Subject must have been referred for cardiac CT angiography OR subject must have undergone clinically indicated SPECT with positive or equivocal findings OR subject must have undergone clinically indicated SPECT with prior cardiac CT angiography that showed moderate or severe stenosis.
• Subject must be 18-85 years of age.
• Subject must provide written informed consent prior to any study-related procedures being conducted.
• Subject must be willing to comply with all clinical study procedures.

You may not qualify if…

• Subject is a pregnant or nursing female.
• Subject has severe asthma or COPD requiring frequent inhaler use.
• Subject has prior diagnosis of obstructive CAD that has not been revascularized.
• Subject with implanted rhythm devices (pacemaker, defibrillator).
• Subject has significant arrhythmia.
• Subject has high grade heart block.
• Subject has resting heart rate < 45 bpm, systolic blood pressure <90 mm Hg, or has consumed caffeine within the last 12 hours.
• Subject has an acute psychiatric disorder.
• Subject is unwilling to comply with the requirements of the protocol.
• Subject has previously entered this study.
• Subject has an allergy against iodinated contrast or pharmaceutical stressors used in this study.
• Subject suffers from claustrophobia.
• Subject has impaired renal function (creatinine > 1.5 mg/dl).
• Subject is in unstable condition.
• ST-elevations, new transient ST changes greater than 0.05mV or T-wave inversions with symptoms.
• Subject cannot safely be administered Lexiscan per prescribing information as as determined by investigator.
• Subject has received interventional (PCI, stenting) or surgical (CABG) treatment that may alter the cardiac condition regarding myocardial perfusion status and/or stenosis degree between cardiac CTA, SPECT, and/or CT stress perfusion studies.

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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