PPV to Guide Fluid Management in the PICU

Completed · Not applicable

Conditions studied: Sepsis, Systemic Inflammatory Response Syndrome

In brief

Children who are critically ill often require large amounts of fluid during their acute illness. It has been shown in multiple studies that appropriate administration of fluid decreases morbidity and mortality, but giving too much fluid can also cause increased morbidity and mortality. It is often difficult to discern from physical exam, vital signs and labs if the amount of fluid that has been given is appropriate or if a pediatric patient requires more fluid. Pulse pressure variation (PPV) is the change in blood pressure when a patient is on a ventilator or breathing machine. PPV has been used in multiple adult studies to help predict fluid needs in a critically ill patient. In this study, we would like to investigate if PPV can help better predict if critically ill pediatric patients in the pediatric intensive care unit (PICU) need fluid. The investigators hope that by having the additional information that PPV can provide, physicians can more judiciously give fluid and thereby improve morbidity of critically ill patients in the PICU.

Key facts

Study ID

NCT02308371

Run by

University of North Carolina, Chapel Hill

People needed

100

Starts

2014-11-01

Expected to finish

2016-06-01

Last updated by the study team

2017-01-02

Who can join

Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admission to the University of North Carolina pediatric critical care unit, includes all patients admitted to the pediatric critical care service as well as all post-operative patients.
• No limitations for age or gender.
• Patient requires standard mechanical ventilation.
• Patient has an arterial line in place.

You may not qualify if…

• Patient not mechanically ventilated.
• Patient does not have arterial line placed.
• Patient requires extracorporeal life support.
• Patient requires placement on high frequency oscillatory ventilation.
• Pulse pressure variation unable to be obtained on monitor.
• Patient has open chest.
• Patient has arrhythmias.

Where it is running

• University of North Carolina — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.