Sickle Cell Hemoglobinopathies and Bone Health
Running, not enrolling
Conditions studied: Sickle Cell Disease, Sickle Cell Trait
In brief
This research study has two purposes. The first purpose is to determine whether having sickle cell trait (SCT) is a risk factor for the development of bone thinning at an earlier age than expected. Nearly 10% of African Americans (AA) carry sickle cell trait and most of them are unaware of it. African Americans are less likely to develop thin bones than whites, but if they sustain a bone fracture, they are more likely to die from it. We believe having sickle cell trait may lead to bone thinning and predispose a subset of African Americans to dangerously thin bones. The second purpose is to try to understand why individuals with sickle cell disease (SCD) have thinner bones than healthy individuals do. Doctors have already discovered that people with sickle cell disease have very thin bones, but they have not determined why. Our study will try to identify whether the bone thinning is from the body not making enough bone or from the body losing bone once it is made.
Key facts
- Study ID
- NCT02306993
- Run by
- UConn Health
- People needed
- 45
- Starts
- 2014-05-01
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-03-27
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Age 18-45 years.
- Female.
- Regular menstrual periods.
- Self-identification of African American race.
You may not qualify if…
- Taking oral contraceptives or medications known to influence bone metabolism (e.g. Glucocorticoids, anti-resorptive or anabolic medications for osteoporosis, pharmacologic Vit D dosing).
- Known metabolic bone disorder (e.g. uncontrolled thyroid disease, hyperparathyroidism).
- Pregnant, breast-feeding, or within 3 months post-partum.
- Taking an investigational drug.
Where it is running
- UConn Health — Farmington, Connecticut, United States
Full record on ClinicalTrials.gov
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