Sildenafil in Heart Failure With Reactive Pulmonary Hypertension

Stopped early · Phase 4 · Has a placebo group

Conditions studied: Heart Failure With Reactive Pulmonary Hypertension

In brief

The purpose of this study is to determine whether Sildenafil 20mg taken three times a day is effective in the treatment of Heart Failure with Reactive Pulmonary Hypertension. This is a double-blind, placebo controlled trial.

Key facts

Study ID

NCT02304705

Run by

Maya Guglin

People needed

33

Starts

2015-01-01

Expected to finish

2017-06-01

Last updated by the study team

2019-11-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Known chronic heart failure appropriately treated with Angiotensin converting enzyme (ACE) inhibitors and beta blockers, unless contraindicated or poorly tolerated
• indication for right heart catheterization
• pulmonary artery mean pressure >25 mmHg
• pulmonary capillary wedge pressure > 15 mmHg
• pulmonary vascular resistance > 3 Wood units

You may not qualify if…

• hypersensitivity, allergy, or intolerable side effect to sildenafil
• history of primary pulmonary hypertension, connective tissue disorder, severe chronic obstructive pulmonary disorder (COPD), pulmonary embolism, or left to right shunt
• co-morbidities, limited exercise intolerance:
• morbid obesity (BMI >40)
• COPD with oxygen dependence
• severe peripheral vascular disease with intermittent claudication
• status post amputation of lower extremity at any level
• severe degenerative joint disease preventing normal walking

Where it is running

• University of Kentucky Medical Center — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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