Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO

Completed · Phase 2 · Has a placebo group

Conditions studied: Macular Edema, Retinal Vein Occlusion

In brief

A phase 2, multicenter, randomized, active-controlled, masked, parallel arm study designed to evaluate the safety and efficacy of a single suprachoroidal injection of CLS-TA, triamcinolone acetonide injectable suspension, given along with an intravitreal (IVT) injection of aflibercept compared to IVT aflibercept alone in subjects with retinal vein occlusion (RVO).

Key facts

Study ID

NCT02303184

Run by

Clearside Biomedical, Inc.

People needed

46

Starts

2015-01-01

Expected to finish

2016-03-01

Last updated by the study team

2021-02-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of macular edema following RVO
• History of ME ≤ 12 months
• 20-70 letters inclusive BCVA using ETDRS

You may not qualify if…

• has had an IVT injection of anti-VEGF for RVO in the study eye
• has had a corticosteroid injection in the past 3 months in the study eye
• any uncontrolled ophthalmic condition in the study eye other than RVO

Where it is running

• Study site — Phoenix, Arizona, United States
• Study site — Beverly Hills, California, United States
• Study site — San Diego, California, United States
• Study site — Boynton Beach, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Baltimore, Maryland, United States
• Study site — St Louis, Missouri, United States
• Study site — Winston-Salem, North Carolina, United States
• Study site — Rapid City, South Dakota, United States
• Study site — Abilene, Texas, United States
• Study site — Houston, Texas, United States
• Study site — McAllen, Texas, United States
• Study site — San Antonio, Texas, United States
• Study site — The Woodlands, Texas, United States

Full record on ClinicalTrials.gov

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