Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)
Completed
Conditions studied: Coronary Artery Disease
In brief
Background: \- This study is designed for people who need a standard, non-research invasive coronary angiogram to find out if they have heart disease. Researchers want to take a computed tomography (CT) scan of people s hearts before their procedure to see if this less invasive test can also diagnose coronary artery disease. Objectives: \- To learn if a new way to view CT pictures is able to accurately diagnose coronary artery disease. Eligibility: \- People age 55 and older who need a coronary angiogram. Design: * Participants will be screened with their medical records. * Participants may give a blood sample. * Participants may have a CT scan of the heart with and without contrast. The CT scan will not interfere with their medical care. * Participants blood pressure and heart rhythm will be monitored before, during, and after the CT scan. They may have an electrocardiogram. * Before the scan, participants will have an intravenous catheter put into their arm. It will be used to inject contrast. * Participants may take a beta blocker to slow their heart rate. * Participants may take nitroglycerin under their tongue. It will enlarge their heart blood vessels and improve picture quality. It may cause a flushing sensation or headache. * Participants will lie on their back on a padded table. The table slides into a large, donut-shaped machine. An x-ray tube will move around their body, taking pictures. They will be asked to hold their breath for 5 seconds at a time. * Participants will be called 30 days after their angiogram. They will answer questions about their health, hospital visits, or medical treatments.
Key facts
- Study ID
- NCT02303067
- Run by
- National Heart, Lung, and Blood Institute (NHLBI)
- People needed
- 13
- Starts
- 2015-01-06
- Expected to finish
- 2018-08-13
- Last updated by the study team
- 2019-12-16
Who can join
Age: 55 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Known allergy to iodinated contrast media
- Estimated GFR less than 50 ml/min
- Atrial fibrillation or other continuous cardiac arrhythmias
- Known or suspected intolerance or contraindication to beta-blocker medication (i.e. significant reactive airway disease, decompensated heart failure, Mobitz type 2 second degree or 3rd degree atrio-ventricular heart block)
- Inability to adequately hold breath for 5 seconds
- Pregnancy. Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study MDCT.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
- Rigshospitalet — Copenhagen, Denmark
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.