A Study of Glembatumumab Vedotin as Monotherapy or in Combination With Immunotherapies in Patients With Advanced Melanoma

Stopped early · Phase 2

Conditions studied: Melanoma

In brief

This study will examine the effectiveness and safety of glembatumumab vedotin as monotherapy or in combination with immunotherapies in patients with advanced melanoma.

Key facts

Study ID

NCT02302339

Run by

Celldex Therapeutics

People needed

132

Starts

2014-11-01

Expected to finish

2018-10-03

Last updated by the study team

2019-09-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Among other criteria, patients must meet all of the following conditions to be eligible for the study:
• Unresectable, histologically-confirmed advanced (Stage III or Stage IV) melanoma
• Disease progression during or after the last anticancer therapy received. For Cohort 3, progression must have occurred during the PD-1 targeted CPI (checkpoint inhibitor) treatment and the investigator has deemed it appropriate to continue treatment with the PD-1 targeted CPI beyond confirmed disease progression
• No more than one prior chemotherapy-containing regimen for advanced disease.
• Prior treatments received must include at least one CPI inhibitor (e.g., anti-CTLA-4, PD-1-, PD-L1-targeted immunotherapy) and for patients with a BRAF mutation at least one BRAF- or MEK-targeted therapy, unless patients are not candidates for, or refused, these therapies. For cohort 3, prior treatment received must include a PD-1 targeted CPI administered during the most recent disease progression and for patients with BRAF mutation at least one BRAF- or MEK-targeted therapy when appropriate
• The study site will submit paraffin-embedded tumor tissue obtained from the patient for gpNMB analysis. Patients may require a biopsy if recent tumor tissue is not available. Patients in cohort 2 and 3 must submit a recently obtained biopsy of the skin fold for gpNMB analysis. Patients in Cohort 4 will submit a tumor tissue sample while on study.
• Eastern Cooperative Oncology Group (ECOG) Performance Status 0 to 1
• Adequate bone marrow, liver and renal function.

You may not qualify if…

• Among other criteria, patients who meet any of the following conditions are NOT eligible for the study:
• Previously received glembatumumab vedotin (CR011-vcMMAE, CDX-011) or other MMAE-containing agents
• Treatment with the following therapies before the planned start of study treatment:
• BRAF or MEK inhibitors within 2 weeks
• Monoclonal based therapies within 4 weeks except for the PD-1 targeted checkpoint inhibitor in cohort 3
• Immunotherapy (tumor vaccine, cytokine, or growth factor given to control the cancer) within 2 weeks
• Chemotherapy within 21 days or at least 5 half-lives (whichever is longer)
• Investigational therapy within 2 weeks (or at least 5 half-lives, whichever is longer)
• Patients with ocular melanoma
• Neuropathy that is moderate (Grade 2) or worse.
• Cancer that has spread to the brain or spine will be discussed with the study sponsor and may exclude patients from the trial.
• History of another cancer except:
• Patients with adequately treated and cured non-melanoma skin cancer or in situ cancer
• Patients with any other cancer from which the patient has been disease-free for ≥ 3 years
• Significant cardiovascular disease
• Previously received varlilumab or any other anti-CD27 mAb (Cohort 2 only)
• Active systemic infection requiring treatment
• Treatment with immunosuppressive medications within 4 weeks or corticosteroids within two weeks
• Patients with interstitial lung disease (Cohort 3 only)
• Patients with active diverticulitis (Cohort 3 only)
• Any non-study vaccination within 4 weeks, or influenza vaccine within 2 weeks, prior to CDX-301 dosing (Cohort 4 only)

Where it is running

• The Angeles Clinic and Research Institute — Los Angeles, California, United States
• Northern California Melanoma Center/St. Mary's Medical Center — San Francisco, California, United States
• Florida Cancer Specialists — Fort Myers, Florida, United States
• Mount Sinai Comprehensive Cancer Center — Miami Beach, Florida, United States
• Florida Cancer Specialists — West Palm Beach, Florida, United States
• Northside Hospital Cancer Institute — Atlanta, Georgia, United States
• University of Chicago Medicine — Chicago, Illinois, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Henry Ford Hospital — Detroit, Michigan, United States
• New York University School of Medicine — New York, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Tennessee Oncology — Nashville, Tennessee, United States
• Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States
• Baylor Research Institute-Sammons Cancer Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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