Cerebellar Mutism Syndrome Study
Recruiting now
Conditions studied: Infratentorial Neoplasms, Mutism
In brief
The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS). Furthermore the purpose is to explore the clinical course and the best treatment of the syndrome.
Key facts
- Study ID
- NCT02300766
- Run by
- Rigshospitalet, Denmark
- People needed
- 1000
- Starts
- 2014-10-01
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2025-09-26
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age < 18 years at the date of first imaging showing this tumour
- Tumour in the cerebellum/4th ventricle/brainstem with intention to treat with surgical resection or open biopsy. Second and further surgeries are also included.
- Informed consent from custodial parent(s)
You may not qualify if…
- None
Where it is running
- Alder Hey Childrens NHS Foundation Trust — Liverpool, United Kingdom (enrolling)
- University Hospital Leuven — Leuven, Belgium (enrolling)
- Motol University Hospital — Prague, Czechia (enrolling)
- Aalborg University Hospital — Aalborg, Denmark (enrolling)
- Aarhus University Hospital — Aarhus, Denmark (enrolling)
- Rigshospitalet — Copenhagen, Denmark (enrolling)
- Odense University Hospital — Odense, Denmark (enrolling)
- Helsinki University Central Hospital — Helsinki, Finland (enrolling)
- Sahlgrenska University Hospital — Gothenburg, Sweden (enrolling)
- Linköping University Hospital — Linköping, Sweden (enrolling)
- Skåne University Hospital — Skåne, Sweden (enrolling)
- Karolinska University Hospital — Stockholm, Sweden (enrolling)
- University Hospital of Umeå — Umeå, Sweden (enrolling)
- Uppsala University Hospital — Uppsala, Sweden (enrolling)
- Medical University of Vienna — Vienna, Austria (enrolling)
- University of Leipzig Medical Center — Leipzig, Germany (enrolling)
- Semmelweis University, 2nd Dept of Pediatrics — Budapest, Hungary (enrolling)
- Ospedale Pediatrico Bambino Gesù — Rome, Italy (enrolling)
- Hospital of Lithuanian University of Health Sciences Kauno klinikos — Kaunas, Lithuania (enrolling)
- Radboud University Nijmegen Medical Centre — Nijmegen, Gelderland, Netherlands (enrolling)
- UMC Utrecht — Utrecht, Netherlands (enrolling)
- Haukeland University Hospital — Bergen, Norway (enrolling)
- St. Olav's Hospital — Trondheim, Norway (enrolling)
- Kuopio University Hospital — Kuopio, Finland
- Oulu University Hospital — Oulu, Finland
Full record on ClinicalTrials.gov
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