A Study of LY2623091 in Healthy Participants

Completed · Phase 1

Conditions studied: Healthy Volunteers

In brief

The first purpose of this study is to evaluate the effect of itraconazole (and possibly diltiazem) on the amount of LY2623091 in the blood stream and how long the body takes to get rid of it. The second purpose of the study is to evaluate the effect of LY2623091 on the amount of simvastatin (and possibly tadalafil) in the blood stream and how long the body takes to get rid of it. The safety and tolerability of LY2623091 when given with itraconazole, simvastatin and diltiazem or tadalafil will be evaluated. There will be three groups of participants in this study. Results from Groups 1 and 2 will be analyzed during the study to determine whether to enroll participants in Group 3 or 4. The study is expected to last up to 40 days from the first dose to follow-up (inclusive). Screening may occur up to 28 days prior to enrollment.

Key facts

Study ID

NCT02300259

Run by

Eli Lilly and Company

People needed

48

Starts

2014-11-01

Expected to finish

2015-04-01

Last updated by the study team

2020-06-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy participants as determined by medical history, physical examination, clinical laboratory tests, and electrocardiograms (ECGs).
• Have a body mass index (BMI) between 18 and 32.0 kilograms per square meter (kg/m\^2) inclusive, at screening
• Female participants must be of non-childbearing potential

You may not qualify if…

• In the opinion of the investigator or sponsor, are unsuitable for inclusion in the study

Where it is running

• Covance Clinical Research Inc — Daytona Beach, Florida, United States

Full record on ClinicalTrials.gov

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