Methadone in Ambulatory Surgery

Completed · Not applicable

Conditions studied: Post-operative Pain, Anesthesia

In brief

The μ-opioid receptor agonist methadone is frequently used in adult anesthesia and adult pain therapy. Methadone has an extremely long half-life, which confers therapeutic advantage by providing more stable plasma concentrations and long-lasting pain relief. Methadone perioperative pharmacokinetics and effectiveness in perioperative pain relief in inpatients is well characterized. There is, however, no information on methadone use in an ambulatory surgery setting and outpatient procedures. This pilot investigation will determine effectiveness of intraoperative methadone in reducing postoperative opioid consumption and providing improved pain relief in patients undergoing moderately painful, ambulatory surgical procedures.

Key facts

Study ID

NCT02300077

Run by

Washington University School of Medicine

People needed

60

Starts

2014-12-01

Expected to finish

2018-02-12

Last updated by the study team

2019-05-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65 years
• Undergoing general anesthesia and moderately painful, ambulatory surgical procedures with anticipated overnight, postop hospital stay of < 24 hours
• Signed, written, informed consent

You may not qualify if…

• History of or known liver or kidney disease.
• Females who are pregnant or nursing.
• Opioid tolerant patients (e.g. preoperative methadone therapy or use of fentanyl transdermal patches)
• History of allergy to methadone

Where it is running

• Barnes-Jewish Hospital — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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