Study to Enhance Motor Acute Recovery With Intensive Training After Stroke

Completed · Not applicable

Conditions studied: Stroke

In brief

Stroke often results in limitation of arm movements, from which many people do not fully recover. We believe that early and intensive therapy is important to enhance recovery of arm movements after stroke. We are doing this research study to see how much arm movements improve with intensive therapy in patients have had a stroke in the past 6 weeks.

Key facts

Study ID

NCT02292251

Run by

Johns Hopkins University

People needed

32

Starts

2015-05-01

Expected to finish

2018-04-01

Last updated by the study team

2018-08-10

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age over 21 years
• Ischemic stroke confirmed by CT or MRI within the previous 6 weeks
• No history of prior ischemic or hemorrhagic stroke with associated motor deficits (prior stroke with no motor symptoms is allowed)
• Residual unilateral arm weakness with Fugl-Meyer Upper Extremity (FM-UE) score 6-40 at time of enrollment.
• Ability to give informed consent and understand the tasks involved.

You may not qualify if…

• Space-occupying hemorrhagic transformation or associated intracranial hemorrhage.
• Arm impairment that is too severe or too mild on day of baseline testing just prior to beginning of the study intervention.
• Recent botox injection to upper limb or planned botox injection over the course of the 7-month study duration.
• Cognitive impairment, with score on Montreal Cognitive Assessment (MoCA) ≤ 20.
• History of physical or neurological condition that interferes with study procedures or assessment of motor function (e.g. severe arthritis, severe neuropathy, Parkinson's disease).
• Inability to sit in a chair and perform upper limb exercises for one hour at a time.
• Participation in another upper extremity rehabilitative therapy study during the study period.
• Terminal illness
• Social and/or personal circumstances that interfere with ability to return for therapy sessions and follow up assessments.

Where it is running

• Johns Hopkins University — Baltimore, Maryland, United States
• Columbia University — New York, New York, United States
• University of Zurich — Zurich, Switzerland

Full record on ClinicalTrials.gov

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