Evaluation of Pharmacokinetic and Pharmacodynamic Properties of Intravenous Colistimethate Sodium

Completed

Conditions studied: Colistin

In brief

Colistin is a polymixin antibiotic used in the treatment of multidrug-resistant gram-negative infections. Given the limited use of colistin and previous challenges with laboratory assays to determine plasma concentrations, there is a lack of knowledge of the pharmacokinetic profile of colistin. The purpose of the investigators observational prospective pharmacokinetic cohort study is to examine the steady-state pharmacokinetic and pharmacodynamic properties of intravenous colistimethate sodium in cystic fibrosis and critically ill patients.

Key facts

Study ID

NCT02288429

Run by

University of Colorado, Denver

People needed

16

Starts

2013-09-01

Expected to finish

2019-06-01

Last updated by the study team

2019-06-24

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥ 18 years old receiving intravenous colistimethate sodium for the treatment of infection
• Have cystic fibrosis and/or are critically ill (admitted to a critical care unit)

You may not qualify if…

• Pregnancy
• Breastfeeding
• Prisoners

Where it is running

• University of Colorado Hospital — Aurora, California, United States

Full record on ClinicalTrials.gov

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